23 0 obj %PDF-1.7 ;:oL*)h,Aqj7'%?f:USB9bv .ikLRJI)X|79S!hb2032%{ri;N*)9Y Bdvk'7$[Mv)/xF%}306~S`FBX$`TWCR^6dA,5 `Wg$?W{%%\ar)dX%}XgBx/^{,'=g{y$ jS1R;N LyW&*<0`5&L\K`cI5w}pD3_ DQFPUU5,(fud&K 5E%uEvA&Gssr|DVb|#'@VahaH PRODUCT AND COMPANY IDENTIFICATION Product Name: Eltrombopag Olamine Product Catalog Number: A3387 CAS Number: 496775-62-3 Company: APExBIO Technology 7505 Fannin street, Suite 410, Houston, TX 77054, USA +1-832-696-8203 TEL +1-832-641-3177 FAX Wear fire/flame resistant and impervious clothing. Clean spillages in a safe way as soon as possible. 13 0 obj <>stream The most important known symptoms and effects are described in the labelling (see section 2.2). Ensure adequate ventilation. !d3"p^g=\-]0{![6 onM=o?o_XP? Ensure adequate ventilation. Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). Eltrombopag is an orally available thrombopoietin receptor agonist which was first approved for use in human patients with refractory idiopathic thrombocytopenia purpura. Buy highly pure Eltrombopag Olamine - API, CAS No : 496775-62-3, Mol.Formula : C29H36N6O6, Mol.Weight : 564.63, from Pharmaffiliates. The toxicological effects of this product have not been thoroughly studied. Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13. The new method was evaluated according to the ICH guideline and as far as validation results are concern correlation coefficient value that was 1.0000 for the compound, percentage recovery 99.4%, and repeatability results relative . Conduct recycling or disposal in accordance with prevailing country, federal, state and local regulations. It inhibits platelet . Wear self-contained breathing apparatus for firefighting if necessary. Rinse skin thoroughly with large amounts of water. : 496775-62-3 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Avoid breathing vapors, mist, dust or gas. If breathing is difficult, give oxygen. 4 0 obj . Try to prevent further leakage or spillage. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. (We`ll never share your email address with a third-party.). Eltrombopag olamine is practically insoluble in aqueous buffer across a pH range of 1 to 7.4, and is sparingly soluble in water. Identified Uses: Laboratory chemicals, Manufacture of substances. x]0{@\O^ Cx|@ Eltrombopag olamine a type of thrombopoietin receptor agonist and is used to treat thrombocytopenia (a lower-than-normal number of platelets in the blood) in patients with chronic immune thrombocytopenic purpura (a condition in which platelets are destroyed by the immune system). This leads to increased destruction of platelets, putting patients at risk of bleeding. For research use only, not for human or veterinary use. Avoid inhalation, contact with eyes and skin. Ticagrelor, the generic version of BRILINTA, developed by AstraZeneca and approved by USFDA in 2011. This study is designed in dose escalation fashion to evaluate safety, pharmacokinetics and efficacy of Hetrombopag Olamine. in vitro: Eltrombopag demonstrated a half maximal . Not for human use. PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted. Sample COA MSDS. Immediately relocate self or casualty to fresh air. Administration of eltrombopag 75 mg once daily for 5 days with a single 10 mg dose of the OATP1B1 and BCRP substrate rosuvastatin to 39 healthy adult subjects increased plasma rosuvastatin C max 103% (90% confidence interval [CI]: 82%, 126%) and AUC 0- 55% (90% CI: 42%, 69%). Avoid contact with skin and eyes. We do not sell to patients. As in any fire, wear self-contained breathing apparatus and protective clothing. Max: 75 mg daily. <>stream Login as registered user for prices, availability and discounts. We warmly welcome you to buy eltrombopag olamine cas 496775-62-3 in stock here from our factory. Use only in areas with appropriate exhaust ventilation. No components are subject to the Pennsylvania Right to Know Act. Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Eltrombopag Olamine is indicated in Chronic Immune (Idiopathic) Thrombocytopenia, Chronic Hepatitis C-associated Thrombocytopenia, Severe Aplastic Anemia. endobj Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. NTP? Prevent fire caused by electrostatic discharge steam. Eltrombopag olamine Safety Data Sheets Characteristics of Eltrombopag olamine Suppliers of Eltrombopag olamine Download SDS (editable Word file) and other types SDS | Offered by XiXisys.com SAFETY DATA SHEETS According to the UN GHS revision 8 Version: 1.0 Creation Date: July 15, 2019 Revision Date: July 15, 2019 SECTION 1: Identification Use personal protective equipment.Wear chemical impermeable gloves. DISCLAIMER HHS VULNERABILITY DISCLOSURE Remove all sources of ignition. endobj MSDS: View or download Product Description: Eltrombopag Olamine (Eltrombopag diethanolamine salt) is a thrombopoietin-receptor agonist used to treat low blood platelet counts with chronic immune thrombocytopenia. Any bruising or bleeding while you take and after you stop taking this medicine (eltrombopag tablets). General Information. Eltrombopag Olamine. Collect and arrange disposal. Eltrombopag olamine Min.Order: 10 Milligram FOB Price: USD $ 0.0-0.0/Milligram 1.Professional synthesis laboratory and production base. Login . Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. C 2 5 H 2 2 N 4 O 4.2 C 2 H 7 NO. WAZ[-TW(7]{7~U`Eq&c2{4+pw#J1/N^DYM]HI>]_7\QElYw8qm+5_#p%W eo$*ng\v~ O"uUzHh{5mou4]>Zk$,(N KWI The product is for research use only and for trained personnel. 1.2. Untuk anemia aplastik: Dosis awal 50 mg 1 kali sehari dan dosis maksimal 150 mg 1 kali sehari. Eltrombopag olamine is included in Bulk Drug Intermediates category. Eltrombopag Olamine owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Stable under recommended storage conditions. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Once-daily oral dosing offers more physiological mimicry than once-weekly subcutaneous administration 4,15,16 The half-life of REVOLADE (approximately 21-32 hours) relative to dosing frequency (every 24 hours) allows for steady drug levels, mimicking endogenous TPO 4,15-17 In healthy subjects, TPO is produced constitutively in the liver 16 Do NOT induce vomiting unless directed to do so by medical personnel. No IARC Monographs? Name:Eltrombopag Olamine,CAS:496775-62-3.Molecular Fomula:C29H36N6O6,Molar Mass:564.6328,MSDS,Hazard,Safety. Separate eyelids with fingers to ensure adequate flushing. Catalogue Number AR-E01197. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations. The burden of safe use of this material rests entirely with the user. 11 0 obj Potential advantages of eltrombopag may include a sustained platelet response and a good tolerability profile. If not breathing, give artificial respiration and consult a doctor immediately. Eltrombopag olamine (CAS No. No ACGIH? AKsynth is the manufacturer & Supplier of compound Eltrombopag Olamine | +91 8454 051 081 info@aksynth.com. Synonym. Eltrombopag olamine was first approved as Promacta on 2008-11-20. Eltrombopag diethanolamine salt; SB-497115GR. It has been approved in Europe to treat thrombocytopenic purpura idiopathic. Stable under recommended storage conditions. Eltrombopag Olamine. Product name : Eltrombopag (Olamine) Catalog No. Avoid dust and aerosol formation. Revolade, INN-eltrombopag / eltrombopag olamine 30 Churchill Place Canary Wharf London E14 5EU United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000Facsimile +44 (0)20 3660 5520 Send a question via our websitewww.ema.europa.eu/contact 28 January 2016 EMA/CHMP/722220/2015 Eltrombopag: CAS Number: 496775-61-2: 1.2 Relevant identified uses of the substance or mixture and uses advised against; Identified uses: For research use only, not for human or veterinary use. Strong acids/alkalis, strong oxidising/reducing agents. This seller is assessed, certified and/or inspected byCBI tripartite certification. Rinse with pure water for at least 15 minutes. (7.2) Polyvalent cations (e.g., iron, calcium, aluminum, magnesium, selenium, The burden of safe use of this material rests entirely with the user. This supplier was in ECHEMIs Top 10 Suppliers list last year. endstream Keep away from direct sunlight and sources of ignition. Never give anything by mouth to an unconscious person. If breathing is difficult, give cardiopulmonary resuscitation (CPR). This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm. If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator. CAS number: 496775-62-3 . This substance is considered to be non-hazardous for transport. Avoid dust formation. Not for human use. I would like to introduce you to Kombucha Tea, if you have not already heard about it. Retention time for Eltrombopag was found to be 2.16 min; and linearity range was 3.516 g/mL-131.862 g/mL. <> ;8b8 NCJ!$;vgw${8X}W:Mw#wHt;,T(-BR{5=^9L|N6v!msGU,%Lf^v:Bz;N Kl[n>OfB^{rge64FVk9VBKC^W$@';vor{mss1^JBvwi\IXE}tT)a{r)DK:71g/o#>:`zw86W5\#%`v]qB1e'_v:u[h7U9b9 7u4z=`j=nyp*A"QEVL{x\H:0G5V "R6,$L6a&5NGO)v1WU_?o*$ >awL J1ml0"e1Yw('tF=5-6q._/ D4; NCATS. Eltrombopag olamine. HNMR ,CNMR,FNMR, HPLC/G Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. Promacta, Revolade (eltrombopag olamine) is a small molecule pharmaceutical. 2-aminoethanol (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate. Avoid mouth-to-mouth resuscitation. Store the container tightly closed in a dry, cool and well-ventilated place. % Fluid, Electrolyte, and Acid-base Balance, View all products of Market Price & Insight, Unii-4U07F515lg 99% Pharm Intermediate Professional Producer Greenbo, Eltrombopag olamine 99% Powder 496775-62-3, ECHEMI - ECHEMI platform complaint penalty rules, Market Analysis - Monthly Report - July 2022- Hot Products, Price trends in the China's chemical market in the first half of 2022, Soybean Oil and Palm Oil Prices Bottom Out, The country's first "hydrolyzed zinc hyaluronate" was successfully filed, Bis-(3-nitrophenyl)-methylphosphine oxide SDS, 5-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile SDS, (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride SDS, 4-(N-Boc-aminomethyl)phenylboronic acid SDS, Toxicity to daphnia and other aquatic invertebrates: no data available, Toxicity to microorganisms: no data available, ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road, RID: Regulation concerning the International Carriage of Dangerous Goods by Rail, IMDG: International Maritime Dangerous Goods, IATA: International Air Transportation Association, IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home, HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm, IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/, eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en, CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple, ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp, ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg, Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp, ECHA - European Chemicals Agency, website: https://echa.europa.eu/. Get medical attention. 2 0 obj Eltrombopag olamine | C29H36N6O6 | CID 135449331 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13. Molecular Formula. Eltrombopag Diethanolamine salt. Hetrombopag Olamine made by Jiangsu Hengrui Medicine co Ltd. has shown an effect of increasing platelet count in animal and human.
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