Do not take a double dose to make up for a missed one. If thromboembolic events occur, promptly institute appropriate treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. (avatrombopag) tablets, for oral use Initial U.S. Approval: 2018 . Avatrombopag: Uses, Interactions, Mechanism of Action - DrugBank Metabolized by CYP2C9 and CYP3A4. Eltrombopag: Uses, Interactions, Mechanism of Action - DrugBank The dose is usually 40 (2 tablets) to 60 milligrams (mg) (3 tablets) once a day for 5 days. If you miss a dose of avatrombopag, take it as soon as possible. Doptelet (avatrombopag) - Drug Insight and Market Forecast report is published on August 6, 2020 and has 80 pages in it. antithrombocytopenics Pharm. Take your next dose at the regular time and stay on your once-daily schedule. Avatrombopag Drug Characteristics. Indications and dose Thrombocytopenia [in patients with chronic liver disease undergoing invasive procedures and platelet count less than 40x109/litre] (under expert supervision) By mouth Adult Comparison of avatrombopag 60 mg vs. placebo, adjusted for the number of chemotherapy agents currently receiving per IWRS (1, 2). ChildrenUse and dose must be determined by your doctor. Doptelet for Liver Disease: Drug Side Effects & Dosage - MedicineNet Avatrombopag: First Global Approval | SpringerLink The presence of other medical problems may affect the use of avatrombopag. What is Doptelet used for and how does it work? Dublin, Dec. 30, 2020 (GLOBE NEWSWIRE) -- The "Doptelet (Avatrombopag) - Drug Insight and Market Forecast - 2030" report has been added to ResearchAndMarkets.com's offering. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. If a moderate or potent dual inhibitor of CYP2C9 and CYP3A4 is initiated in a patient already receiving chronic avatrombopag therapy, adjust the dosage of avatrombopag based on platelet count monitoring. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Blood clotting disorder (eg, antithrombin deficiency, Factor V Leiden, prothrombin 20210A or, Protein C or S deficiency)Use with caution. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Avatrombopag (Doptelet) | Davis's Drug Guide Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations This medication increases the production of platelets by your body to help prevent too much bleeding from the procedure.Avatrombopag is also used to treat people with a certain blood disorder. Pharmacokinetics not substantially altered in patients with mild or moderate renal impairment (Clcr 30 mL/minute). Blood clots, history ofUse with caution. Store at 2025C (excursions permitted to 1530C). All Rights Reserved. Importance of patients immediately informing their clinician if signs and symptoms of a blood clot (e.g., swelling, pain, or tenderness in the leg, tachycardia, shortness of breath, abdominal pain or tenderness, or chest pain) occur. Class. It is also used to treat thrombocytopenia in patients with chronic immune thrombocytopenia who have had previous treatment that did not work well. Platelet count <40,000/mm3: 60 mg once daily for 5 days. If you are taking avatrombopag to treat chronic immune thrombocytopenia, take the missed dose as soon as you remember it. Avatrombopag | C29H34Cl2N6O3S2 - PubChem Davis Drug Guide PDF. DGIdb, The Drug Gene Interaction Database, is a research resource that can be used to search candidate genes or drugs against the known and potentially druggable genome. It is also used to treat thrombocytopenia in patients with chronic immune thrombocytopenia who have had previous treatment that did not work well. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Available for Android and iOS devices. Drug class: Platelet-stimulating agents. Effectiveness and Safety of Avatrombopag in Liver Cancer Patients with At first, 20 milligrams (mg) (1 tablet) once a day. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Copyright, 2022. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Call your doctor for medical advice about side effects. Mulpleta vs Doptelet - What's the difference? Hemodialysis not expected to affect elimination. Avatrombopag - Swedish Orphan Biovitrum - AdisInsight thrombopoietin receptor agonists American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. It is also used to treat thrombocytopenia in patients with chronic immune thrombocytopenia who have had previous treatment that did not work well. Your doctor may adjust you dose as needed. What is Doptelet used for and how does it work? Last updated on Aug 24, 2022. Avatrombopag was present in the milk of lactating rats. 1 (Lambert et al. in the drug label. For the treatment of thrombocytopenia in people with ITP, it is usually taken once daily with food for as long as directed. P-gp inhibitors: Clinically important pharmacokinetic interaction not expected. BACKGROUND . Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Upon completion of avatrombopag administration, the platelet count was monitored every 2-4 days from . Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Find information on Avatrombopag (Doptelet) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. NDC 71369-020 Doptelet Avatrombopag Maleate Tablet, Film Coated Oral Follow all directions on your prescription label and read all medication guides or instruction sheets. Non-Guideline-Supported Use. If chronic avatrombopag therapy (i.e., for the treatment of chronic ITP) is initiated in a patient receiving a moderate or potent dual inducer of CYP2C9 and CYP3A4, increase the starting dosage of avatrombopag to 40 mg once daily. Call your doctor if you have any unusual problems while taking this medication. Weak inducer of CYP2C8 and CYP2C9 in vitro but does not induce CYP isoenzymes 1A, 2B6, 2C, or 3A or inhibit CYP isoenzymes 1A, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, or 3A in vitro. Corticosteroids remain the standard initial therapy for newly diagnosed patients with ITP, but should be used for a limited duration only because of adverse effects. Do not take other medicines unless they have been discussed with your doctor. It is also used to treat thrombocytopenia in patients with chronic immune thrombocytopenia who have had previous treatment that did not work well. If a dose is missed, take the dose as soon as it is remembered. PDF CENTER FOR DRUG EVALUATION AND RESEARCH - Food and Drug Administration May make these conditions worse. Consider potential increased risks of thrombotic and thromboembolic complications in patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (e.g., factor V Leiden, prothrombin 20210A, antithrombin deficiency, protein C or S deficiency). Safety and efficacy have not been established. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule, but be sure to finish taking all of the medication (even if they are not taken 5 days in a row). May cause fetal harm based on animal findings. Avatrombopag - Wikipedia This report provides a detailed market assessment of Doptelet (avatrombopag) in Seven Major Markets, i.e., United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. An evaluation of avatrombopag for the treatment of - ResearchGate This prospective, open-label, single-center, one-arm clinical trial aims at evaluating the efficacy and safety of avatrombopag in Chinese adult Immune Thrombocytopenia (ITP) patients with autoantibodies fail (due to intolerance or resistance) to eltrombopag or herombopag treatment. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Avatrombopag (Doptelet) - Everyday Health Avatrombopag is also used to treat chronic immune thrombocytopenia when other treatments have failed. Follow all directions on your medicine label and package. Dose level 5: 40 mg 3 times per week and 20 mg/day on the other 4 days of the week. Drug class: platelet-stimulating agents Avatrombopag systemic is used in the treatment of: Idiopathic Thrombocytopenic Purpura Thrombocytopenia Chemical structure Chemical structure of avatrombopag Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Swedish Orphan Biovitrum AB (publ) Postal address SE-112 76 Stockholm, Sweden. thrombopoietin receptor agonists What are the possible side effects of Doptelet? The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. <50,000/mm3 after at least 2 weeks of avatrombopag therapy, Increase dosage by 1 dose level (see Table 2); wait 2 weeks to assess the effects of this and any subsequent dosage adjustments, Decrease dosage by 1 dose level (see Table 2); wait 2 weeks to assess the effects of this and any subsequent dosage adjustments, Interrupt therapy and monitor platelet count twice weekly; once platelet count <150,000/mm3, restart at a dosage reduced by 1 dose level (see Table 2), <50,000/mm3 after 4 weeks of therapy with avatrombopag 40 mg daily (highest recommended dosage), >400,000/mm3 after 2 weeks of therapy with avatrombopag 20 mg weekly (lowest recommended dosage), 40 mg once daily (highest recommended dosage), 40 mg 3 times a week and 20 mg on the 4 remaining days of each week, 20 mg once daily (usual initial recommended dosage), 20 mg once weekly (lowest recommended dosage). In poor or intermediate CYP2C9 metabolizers (i.e., patients with CYP2C9*2 or *3 polymorphism), systemic exposure is approximately 1.4-fold or 2-fold higher, respectively, compared with CYP2C9 extensive metabolizers. Hetrombopag: First Approval | SpringerLink Dual CYP2C9 and CYP3A4 inhibitors: Moderate or potent dual inhibitors of CYP2C9 and CYP3A4 may result in increased avatrombopag exposure and increased risk of toxicity. Using avatrombopag with any of the following medicines is usually not recommended, but may be required in some cases. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Slightly higher avatrombopag exposures observed in intermediate or poor CYP2C9 metabolizers compared with CYP2C9 extensive metabolizers; not considered clinically important. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Before a scheduled medical procedure: Call your doctor for instructions if you miss a dose. What side effects can this medication cause? Store tablets in original package. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. ChildrenUse and dose must be determined by your doctor. Your doctor will measure your platelet levels weekly to determine how long to treat you with avatrombopag. Treatment of thrombocytopenia in patients with chronic immune thrombocytopenia (ITP; also known as idiopathic thrombocytopenic purpura) who have had an insufficient response to a prior treatment (designated an orphan drug by FDA for use in this condition). Clinical efficacy of avatrombopag and recombinant human thrombopoietin avatrombopag - Medscape Drugs & Diseases Importance of instructing patients or caregivers to read the manufacturers patient information. Store it at room temperature and away from excess heat and moisture (not in the bathroom). The dosage would be increased by 20 mg/day every 2 weeks if the platelet count remains less than 2010e9/L and reduced if the platelet count reaches over than 15010e9/L. Due to the potential for serious adverse reactions in a breastfed child from Doptelet, breastfeeding is not recommended during treatment with Doptelet and for at least 2 weeks after the last dose On May 21, 2018, the Food and Drug Administration approved avatrombopag (Doptelet, AkaRx Inc.) for thrombocytopenia in adults with chronic liver disease scheduled to undergo a procedure. AVATROMBOPAG chembl:CHEMBL2103883 Approved. Written by ASHP. http://www.upandaway.org. Doptelet (avatrombopag) is a second generation, once daily, orally administered TPO receptor agonist approved for the treatment of thrombocytopenia in adult patients with CLD who are scheduled to undergo a procedure. We comply with the HONcode standard for trustworthy health information. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Adjust dosage based on platelet count response (see Table 1). This new drug application provides for the use of Doptelet (avatrombopag) tablets for treatment There is limited information regarding avatrombopag Off-Label Non-Guideline-Supported Use and Dosage (Adult . With its low side-effect burden, absence of hepatotoxicity, ease of use as an oral medication, and lack of food-drug . For thrombocytopenia in patients with chronic liver disease: AdultsDose is based on your platelet count and must be determined by your doctor. Doptelet is a thrombopoietin receptor agonist (TPO-RA) approved for the treatment of severe thrombocytopenia in adult patients with chronic liver disease (CLD) who are scheduled to undergo an . If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Be sure to mention any of the following: fluconazole or rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Buy Avalet 20mg online- Generic Avatrombopag- Drug International Pharma Administration Should be taken with food. Avatrombopag for the treatment of immune thrombocytopenia and Promacta (eltrombopag): Basics, Side Effects & Reviews - GoodRx You may have your medical or dental procedure 5 to 8 days after the last dose of avatrombopag. Following oral administration, peak plasma avatrombopag concentrations occur at 56 hours. Follow recommended dosage guidelines to achieve target platelet counts to minimize risk of bleeding; do not use to normalize platelet counts. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Avatrombopag is a thrombopoietin receptor agonist and is currently marketed under the brand name Doptelet. Avatrombopag, sold under the brand name Doptelet, is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure. Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease who are scheduled to have a medical or dental procedure to help prevent bleeding complications. Recent developments in pharmaceutical salts: FDA - ScienceDirect If chronic avatrombopag therapy (i.e., for the treatment of chronic ITP) is initiated in a patient receiving a moderate or potent dual inhibitor of CYP2C9 and CYP3A4, reduce the starting dosage of avatrombopag to 20 mg 3 times a week. For avatrombopag, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to avatrombopag or any other medicines. Avatrombopag is used to treat thrombocytopenia (low platelets in the blood) in adults with chronic liver disease who are scheduled to have a medical or dental procedure. Do not take a double dose to make up for a missed one. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. How do you take Doptelet before a medical or dental procedure?
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